,18 Here, we show in colonic EECs, obesity was associated with an altered RGS profile, with differential expression patterns in colonic RGS2 (underexpression), RGS4 (underexpression), RGS9 (overexpression), and RGS12 (overexpression). The gene discussed is RGS2; the disease is obesity due to melanocortin 4 receptor deficiency.