There were no differences between Setd1a+/- and WT mice in the total distance moved during the test (Fig 4I, main effect of GENOTYPE, F1,73 = 0.002, p = 0.97) suggesting an equivalent propensity to explore the maze, and as expected, all of the mice showed an avoidance of the more anxiety-inducing open arms of the EPM (Fig 4J, main effect of ARM, F1,73 = 7.41, p = 0.008), and there were no significant effects of SEX or interactions. This evidence concerns the gene SETD1A and Anxiety.