Typhaneoside enhances the expression of p62 protein, increases the p-Akt/Akt and p-mTOR/mTOR ratios, and significantly reduces the number of autophagosomes and the LC3-II/LC3-I ratio in HF rats, which means that typhaneoside reduces autophagy and enhances cardiac function through the PI3K/Akt/mTOR signaling pathway [37]. This evidence concerns the gene AKT1 and hydrops fetalis.