Supporting this notion, analysis of publicly available human scRNA-Seq datasets (6) revealed an 8-fold increase in the percentage of TET3-overexpressing macrophages (TET3 OE Mac) in peritoneal lesions from patients with endometriosis (Endo) as compared with eutopic endometrium from nonendometriosis women (Ctrl) (Figure 1, A and B). The gene discussed is TET3; the disease is endometriosis.