Diabetes is the most expensive chronic condition in the US, and individuals with diabetes account for almost 1 out of every 4 dollars spent on health care.1,2 Approximately 38 million individuals have diabetes, and more than 7 million use 1 or more formulations of insulin.1,2,3,4 Of those, around 2 million have type 1 diabetes, which requires lifelong insulin therapy.3 The gene discussed is INS; the disease is diabetes mellitus.