CD4 and neoplasm: TILs consist of T cells, B cells, and natural killer (NK) cells, while T cell subsets include CD8 + cytotoxic T cells, CD4 + T helper cells, FOXP3 + regulatory T cells, memory T cells, and NK cells.TILs infiltrate stroma and tumor cells, modulate host immune responses to tumor cells, and are significant in combating tumors.