For example, Sulf2-deficient mice have worse outcomes in models of osteoarthritis [62], myocardial infarction [63], and bleomycin-induced lung injury [64], which has been attributed to impaired bone morphogenetic protein [62] and vascular endothelial growth factor [63] signaling and elevated fibroblast growth factor 2 [62] and TGFb [64] signaling. This evidence concerns the gene TGFB1 and osteoarthritis.