SOD1 and amyotrophic lateral sclerosis: In our study, patients carrying the most common SOD1 variants R116G (31% vs. 29% of cases), D91A (12% vs. 11% of cases), and L145F (7% vs. 11% of cases) [15] were detected with a similar frequency compared to previously reported results from a large German study including only patients with familial ALS [15].