In summary, although patients with SOD1-ALS carrying R116G, D91A or L145F variants showed broad commonalities, we obtained some relevant differences, including a faster progression rate with shorter survival, but also shorter diagnostic delay in patients with R116G, and a comparatively benign disease course and high share of patients with negative family history in patients with D91A. This evidence concerns the gene SOD1 and amyotrophic lateral sclerosis.