For example, in the United States, A5V (exon 1) has been described to be the most common pathogenic variant of SOD1-ALS, accounting for approximately 50% of all SOD1 cases, and has been thoroughly characterized by Cudkowicz et al. [11–13], whereas in China, H47R (exon 2) is the most frequent pathogenic variant [14]. This evidence concerns the gene SOD1 and amyotrophic lateral sclerosis.