The special need for a clinical characterization of patients with SOD1-ALS in the German population becomes also evident by the fact that a useful web-tool, recently developed by Spargo et al.[33], which allows easy comparison of age of onset and disease duration among different SOD1 variants, contains data of 1383 SOD1-ALS patients (A5V n = 312, D91A n = 83, L145F n = 69) [33], but only of one patient with R116G, which was found in 31.3% of the patients in our cohort. This evidence concerns the gene SOD1 and amyotrophic lateral sclerosis.