Whereas in SOD1-ALS with R116G and L145F variants more male than female patients were affected (R116G: 69.2% vs. 30.8%; L145F: 66.7% vs. 33.3%), the D91A variant was more frequently found in females (60.0% vs. 40.0%), although these differences did not reach statistical significance. The gene discussed is SOD1; the disease is amyotrophic lateral sclerosis.