It is important to note that the vast majority of reportedto date studies on Tau aggregation were performed in the presenceof heparin, a negatively charged polysaccharide that facilitates Tauaggregation.7,8,11,13−15,17,28 However, the presence of thisanionic molecule may not entirely represent physiological processesthat occur in the brain upon AD and Tauopathies as well as obscurethe clarification of protein–lipid interactions. Here, MAPT is linked to Alzheimer disease.