Recently, the first human genome-wide association study (GWAS) was published, which identified three loci that associate with Lyme disease: rs9276610 in the HLA locus, the TLR1/6/10 expression quantitative trait locus rs17616434, and a missense variant rs2232950 in Secretoglobin family 1D member 2 (SCGB1D2) (56). Here, TLR1 is linked to Lyme disease.