Genes characterizing osteoblast markers and function such as ALP, Col I, OPN, OC, Runx2, IGF1, FGF2, RANKL, OPG, MMP2, and VEGF are upregulated under OM.35 These genes together with adhesion genes including Int α1, Int β1, vinculin, and Src did not alter after ALN treatment. This evidence concerns the gene IGF1 and ocular melanoma.