The results also indicated that low levels of AZIN1 predict dismal prognosis in KIRC (Figure 1A,B), which might be associated with Tregs via dampening the immune system in KIRC discussed above.Our studies indicated that the possible mechanism of the anti‐tumor effect of increased AZIN1 and polyamine levels in KIRC might be the result of the production of toxic metabolites as well as their influence on cancer immunity. This evidence concerns the gene AZIN1 and cancer.