Her group established UBR7 as a novel histone H2B monoubiquitin ligase that suppresses tumorigenesis and metastasis (Dasgupta et al., 2022) and suggested that UBR7 relates to Triple-negative BC (TNBCs) metastasis by remodelling the matrix via TGFβ signalling, thereby altering collagen content and lysyl oxidase activity. The gene discussed is UBR7; the disease is breast cancer.