Furthermore, a stop-to-sense variant in FEM1B (Mutation ID, COSM1729087; c.1883A>T; p.*628L; pathogenicity score, 0.9796), which would rapidly degrade the protein, has been observed in hepatocellular carcinoma (http://NonStopDB.dkfz.de). This evidence concerns the gene FEM1B and hepatocellular carcinoma.