CPT1A and fatty liver disease: AMPK activation also enhances PPARα expression by triggering the AMPK/PGC1α signaling axis, promoting fatty acid oxidation, and ameliorating hepatic steatosis to upregulate the expression of carnitine palmitoyltransferase 1A (CPT1A) and acyl coenzyme a oxidase 1 (ACO1) (Li et al., 2022; Lin et al., 2021).