Luteolin exhibits various mechanisms to alleviate ALI, including the activation of Treg/IL‐10 to alleviate caspase‐11‐dependent pyroptosis (Zhang, Zhang, et al., 2021), activation of epithelial sodium channels via the cGMP/PI3K pathway (Hou et al., 2022), activation of ERK1/2‐ and Ca2+‐dependent HO‐1 induction (Park et al., 2018), and inhibition of Akt/NFκB, MAPK/NFκB, MEK/ERK, and PI3K/Akt pathways (Kuo et al., 2011; Lee et al., 2010; Li et al., 2012). The gene discussed is HMOX1; the disease is acute respiratory distress syndrome.