HRD status, a critical indicator for treatment selection and prognosis in various tumors, demonstrates significant positive correlations with FCN1 in Basal-like BRCA and OV, while displaying negative associations with Mesothelioma (MESO) and Lung Squamous Cell Carcinoma (LUSC) (Supplementary Figure S3F). The gene discussed is FCN1; the disease is squamous cell lung carcinoma.