Periodontitis-induced inflammation and oxidative stress can lead to arterial stiffness, vascular dysfunction, and hypertension (Czesnikiewicz-Guzik et al., 2019; Munoz et al., 2020), and can activate the renin-angiotensin system, causing the release of Angiotensin II (Viafara-Garcia et al., 2019). The gene discussed is REN; the disease is periodontitis.