RCE was found to induce Beclin-1-independent autophagy and caspase 7-dependent apoptosis through proteasome-mediated degradation of Beclin-1, mTORC1, and AKT, and pro-caspase-3, respectively in colon cancer cells (Athamneh et al., 2017). This evidence concerns the gene BECN1 and colonic neoplasm.