Cyclin E, which regulates the G1/S phase transition, has been reported to be highly expressed in pancreatic cancer and promotes pancreatic adenocarcinoma (Liu Z. et al., 2020), and its downregulation suppresses pancreatic tumorigenesis (Franco et al., 2014; Liu B. et al., 2020). The gene discussed is CCNE1; the disease is pancreatic neoplasm.