BECN1 and malignant colon neoplasm: We also assessed the levels of Beclin-1, a component of the PI3KC3 autophagic complex (Klionsky et al., 2021), as previously we reported contrasting results: canonical Beclin-1-dependent autophagy in triple negative breast cancer (El Hasasna et al., 2015) and non-canonical Beclin-1-independent autophagy colon cancer cells (Athamneh et al., 2017).