NLRP3 and hepatitis C virus infection: In hepatitis C-infected livers, the activation of SREBP and NLRP3 is mutually observed, and in the liver of STZ-induced diabetic rats, suppression of TNXIP causes concurrent downregulation of SREBP and NLRP3 activity (Wang W. et al., 2013; McRae et al., 2016).