The role of PCSK9 as a predictor of the risk of atherosclerosis is evident from its gain-of-function mutation, which correlates with the occurrence of conditions, such as coronary heart disease (CAD), abdominal aortic aneurysm, peripheral artery disease, and stroke (Ferreira et al., 2020; Qin et al., 2021; Sawada et al., 2022). The gene discussed is PCSK9; the disease is stroke disorder.