Subsequently identified as the third pathogenic gene associated with familial hypercholesterolemia, along with low-density lipoprotein receptors (LDLRs) and apolipoprotein B (ApoB) genes, PCSK9 has been extensively studied concerning its interplay with lipid homeostasis (Abifadel et al., 2003). This evidence concerns the gene APOB and familial hypercholesterolemia.