Similarly, for the nitrergic system, intestinal pathology in SCA7 mice was associated with a decline in NOS+ neurons in both DSI (10.40 ± 0.35 for Tg-vehicle vs. 27.10 ± 0.54 for untreated C57Bl6, p < 0.0001) and colonic tissues (12.80 ± 0.24 for Tg-vehicle vs. 55.20 ± 1.91 for C57Bl6) (Figures 5A–C). This evidence concerns the gene NOS1 and spinocerebellar ataxia 7.