For example, α1-AT deficiency is more common among Caucasians (up to 20%) (16), citrin deficiency has been found to be a common cause of IC among East Asians (5%) (17), and Niemann–Pick disease type C1 is important cause among the French Canadian of Acadian descent (18). The gene discussed is SLC25A13; the disease is alpha 1-antitrypsin deficiency.