In pulmonary fibrosis tissues, the activity of the Notch pathway is significantly enhanced, and the expression of the Notch signaling pathway regulator Hes1 is increased, which can cause a linkage reaction between fibroblasts and myofibroblasts; this reaction promotes the transformation of myofibroblasts, thereby promoting pulmonary fibrosis [27]. This evidence concerns the gene HES1 and pulmonary fibrosis.