Recent studies have shown that CRY1 inhibits the growth of triple-negative breast cancer (TNBC) cells, which is associated with its inhibition of Pyruvate Dehydrogenase Kinase 1 (Pdk1) expression, Pyruvate Dehydrogenase (PDH) phosphorylation, and glucose depletion (28). The gene discussed is PDK1; the disease is triple-negative breast carcinoma.