In the TCGA–BLCA cohort, KDM6A, FGFR3, STAG2, OBSCN, BIRC, ADGRV1, DST, ABCA13, USP34, and TENM3 had more frequent mutation in samples with low PRKG1 expression. The gene discussed is KDM6A; the disease is bladder transitional cell carcinoma.