Autophagy, EMT, tumor stemness, aberrant tumor microenvironment (TME), and some other cellular progressions have been thought to be related to therapy resistance (6)—for example, SIRT1 induces cisplatin resistance in bladder cancer T24 cells through Beclin1-deacetylation-mediated autophagy activation (7). Here, SIRT1 is linked to neoplasm.