PNPLA3 and hepatocellular carcinoma: While in our study, the PNPLA3 SNP had only weak associations with both HCC risk and overall HCC-associated metabolite changes, the two acyl-cholines arachidonoylcholine and dihomo-linolenoyl-choline, and the lysophospholipid 1-arachidonoyl-GPC (20:4n6) were negatively associated with the PNPLA3 rs738409 risk allele G.