TGFB1 and colorectal cancer: Another histological observational study showed that MCs in locally advanced primary colorectal cancer also differentiated into CAFs via MMT (Type II EMT) (Gordillo et al., 2020), and RNA sequencing analysis showed that TGF-β was associated with MMT (Rynne-Vidal et al., 2017); therefore, whether MCs also differentiate by activating TGF-β needs to be further investigated.