In addition, a study of high-throughput differential secretome analysis of CAFs in colon cancer and non-cancer-activated bone marrow-derived MSC revealed that tenascin C, fibronectin ED-A domain and SDF-1 may also be biomarkers for CAFs in CRC (De Boeck et al., 2013). The gene discussed is CXCL12; the disease is colorectal carcinoma.