This in turn increases matrix stiffness and cancer cell invasion (Pankova et al., 2016; Sahai et al., 2020) and it has been found that lysyl oxidase-like 2 (LOXL2) is overexpressed in CAFs of CRC, which could be used as a marker for predicting the prognosis of colon cancer patients (Torres et al., 2015). Here, LOXL2 is linked to cancer.