MYEOV and esophageal squamous cell carcinoma: They have also been linked together in esophageal squamous cell carcinomas where co-amplification of both genes leads to epigenetic silencing of MYEOV (Janssen et al., 2000; Janssen et al., 2002b) and in primary plasma cell leukaemia where the t(11;14) chromosomal rearrangement leads to IGH super-enhancers being juxtaposed next to MYEOV and CCND1 leading to overexpression of both genes (Coccaro et al., 2016).