Our previous analyses suggest potential regulatory connections between MYEOV and the proto-oncogene CCND1. We observed that in the multiple myeloma (MM) cell line U266, the insertion of the immunoglobulin heavy chain (IGH) Eα1 super-enhancer upstream of CCND1 not only changes the chromatin state surrounding CCND1 but also alters the chromatin configuration of the MYEOV gene. Here, MYEOV is linked to plasma cell myeloma.