Our previous analyses suggest potential regulatory connections between MYEOV and the proto-oncogene CCND1. We observed that in the multiple myeloma (MM) cell line U266, the insertion of the immunoglobulin heavy chain (IGH) Eα1 super-enhancer upstream of CCND1 not only changes the chromatin state surrounding CCND1 but also alters the chromatin configuration of the MYEOV gene. This evidence concerns the gene MYEOV and AL amyloidosis.