AR has been shown to bind to introns of EWSR1 and WT1 (Lamhamedi-Cherradi et al., 2022; Magrath et al., 2024c), raising a tantalizing possibility that similar AR-induced chromosomal translocation could be responsible for generating the pathognomonic alteration and the male predominance in DSRCT. The gene discussed is AR; the disease is desmoplastic small round cell tumor.