Conversely,age, persistent AF, diabetes, congestive heart failure, CHA2DS2-VASc score,anticoagulants, NT-proBNP, LA diameter, LVEDd, E/e’ ratio, sPAP, LAAmax,LAAT/dense SEC, LAA ostium, and LAA depth were negatively correlated with aMAPSE.In the multivariate analysis, aMAPSE independently correlated with persistent AF,LAA-EV, conjunction thickening ratio, and LAA FAC (Table 7). The gene discussed is NPPB; the disease is diabetes mellitus.