Among those withdiabetes, atherosclerotic cardiovascular disease (CVD) is the leading cause ofmorbidity and mortality and the cause of disability and reduced quality of life.Lifestyle exercise promotion has been a cornerstone in diabetes management foralmost as long as the use of insulin and it has been shown that measuredcardiorespiratory fitness (CRF) among diabetes subjects is the strongestpredictor of mortality. The gene discussed is INS; the disease is diabetes mellitus.