The levelsof oxidized phospholipids (ox-PLs) and oxidized low-density lipoprotein (ox-LDL)are elevated in the serum of patients with hyperlipidemia, which increasesoxidative stress and the inflammatory response in the endothelium, as wellenhancing the phenotypic transition of VSMCs into mature osteoblasts andmineralization by upregulating Osx expression, thereby leading to the initiationof CAC [34, 35]. The gene discussed is SP7; the disease is hyperlipidemia.