IL6 and endothelial dysfunction: The main circulating biomarkers identified have been related to myocardialinjury (i.e., NPs, cardiac troponins), extracellular fibrosis (i.e., ST2,galectin-3, metalloproteinases), inflammation markers (i.e., interleukin-6 (IL-6), pentraxin,tumor necrosis factor-alfa (TNF-alfa)), and markers of endothelial dysfunction(i.e., endothelin-1, vascular cell adhesion molecule (VCAM)).From a metabolomic point of view, impairment of several pathways was identified.In particular, the role of lipids, energy, inflammation, endothelial impairment,and increased collagen synthesis has been shown [22].