A reduction in IGF-I and insulin levels has been proposed as a potential cause of neurological disorders in diabetes, as administration of IGF-I can prevent cognitive decline (Ishii and Lupien, 1995; Guo et al., 1999; Ishii and Lupien, 2003; Zegarra-Valdivia et al., 2019). The gene discussed is INS; the disease is Mental deterioration.