ATF4 and neoplasm: In contrast with normal tissues, the ATF4 signaling scores were significantly higher in multiple tumor tissues, such as BRCA, COAD, ESCA, HNSC, KIRC, KIRP, LUAD, LUSC, and STAD (Fig. 1D–G; Fig. S3A–E), while the score was decreased in PRAD (Fig. S3F).