ATF4 and cancer: The ATF4 signaling score was detected to be positively associated with multiple pan-cancer malignant pathways, such as MYC targets, mTORC1, TNF-α signaling via NF-κB, DNA repair, hypoxia, and IL6/JAK/STAT3 signaling, while it was negatively associated with Notch and Wnt/β-catenin signaling.