It was indicated that hypothyroidism is associated with high levels of LDL-C and adverse effects in the number, size, and oxidation of LDL-C [21]. Deficiency of T3 and T4 can increase TG levels by inhibiting the activity of the enzyme lipoprotein lipase [22]. A study reported that hypothyroidism patients who have serum TSH (>10 mIU/L) also have high levels of small and dense LDL-C that have more atherogenic characteristics [23]. In addition, a meta-analysis study by Rudoni et al. indicated that hypothyroidism was linked with chronic heart disease (CHD) risk factors. This evidence concerns the gene LPL and hypothyroidism.