In response to injury environmental signals, BST2-expressing CH cells: i) proliferated; ii) modified the expression profile of specific cell motility-associated genes and migrated toward the damaged site; iii) responded to the systemic factor Hepatocyte Growth Factor Activator (HGFA), a stimulus inducing the transition of quiescent progenitor cells into the GALERT state described by (Rodgers et al., 2017). Here, HGFAC is linked to cyclic hematopoiesis.