The documented AEs, classified by the CTCAE severity scale, include the following: Grade 1: ALT elevation (patients no. 1 and 5), thrombocytopenia (patient no. 1), anemia (patient no. 5), xeroderma (patient no.5), and proteinuria (patient no.4); Grade 2: Fatigue (patient no. 2) and stomatitis (patient no.5); Grade 3: Hypertension (patients no. 2 and 5) and proteinuria (patient no.5). The gene discussed is GPT; the disease is Thrombocytopenia.