GH1 and pituitary tumor: Table 2 lists the top genes that were differentially expressed in GH-secreting pituitary tumors relative to normal pituitaries. Figure 1 illustrates genes that differentially exhibited changes in expression in tumor tissues compared to those in normal tissues. The transcriptomic data revealed numerous DEGs, with 1794 downregulated and 1317 upregulated genes in GH-secreting adenomas relative to normal pituitary tissues, using a threshold of |log2 fold change| > 1 and an adj P-value < 0.05 (Figure 1B).