MAPT and multiple system atrophy: These parameters connect the amyloid structure to its physiological impacts through an integrated system known as the nucleated polymerization model (NPM) (Nowak et al., 1998; Masel et al., 1999), which also captures the behavior of non-infectious amyloids such as α-synuclein in Parkinson’s Disease and Multiple System Atrophy (MSA) and Aβ and tau in Alzheimer’s disease, among others (Jucker and Walker, 2013; Walker et al., 2013).