SIRT1 and preeclampsia: Our study found that patients with severe preeclampsia increased systolic blood pressure, diastolic blood pressure and random protein levels, decreased serum SIRT1 levels, and femoral length, biparietal diameter, head circumference, and neonatal weight in patients with preeclampsia complicated by fetal growth restriction and serum SIRT1 levels decreased, suggesting that serum SIRT1 levels may be closely related to the severity of preeclampsia and whether combined with fetal growth restriction.