To examine the relationship between serum SIRT1 levels and uterine artery hemodynamics and fetal growth restriction, spearman correlation analysis was further performed, and the results showed that serum SIRT1 levels was positively correlated with femoral length, biparietal diameter, head circumference and neonatal weight relationship (p < 0.001) (Figure 4); arterial blood flow velocity peak-to-trough ratio, pulsatility index, resistance index were negatively correlated with femoral length, biparietal diameter, head circumference, and neonatal weight (p < 0.001) (Figure 4). The gene discussed is SIRT1; the disease is fetal growth restriction.