Furthermore, to evaluate the diagnostic and predictive value of serum SIRT1 levels combined with uterine artery hemodynamics, we performed unsupervised PCA analysis, supervised PLS-DA analysis, and cluster heat map analysis, and found that serum SIRT1 levels combined with uterine artery hemodynamics The biological parameters can effectively distinguish between the disease severity and the complicated fetal growth restriction in patients with preeclampsia. The gene discussed is SIRT1; the disease is fetal growth restriction.