Unsupervised PCA analysis of fetal growth restriction in preeclampsia with serum SIRT1 levels combined with uterine artery hemodynamics showed that the groups tended to be clustered and tended to be discrete (Figure 7A); The PLS-DA analysis also showed that the group with fetal growth restriction and the uncombined group were significantly separated in the PC1 dimension, suggesting that the preeclampsia patients with or without fetal growth restriction were similar within the group, and the difference between the groups was significant (Figure 7B). The gene discussed is SIRT1; the disease is fetal growth restriction.