Apelin inhibited the activation of NF-kB which could be the proposed mechanism fordiminished values of pro-inflammatory cytokines in pancreas of mice with chronicpancreatitis that were administered apelin. Accordingly, the pancreatic up-regulationof tumor necrosis factor-a, ICAM, IL-1β, were blocked by apelin. This evidence concerns the gene APLN and chronic pancreatitis.