Degradation and inactivation of TNF-α by pancreatic proteases implies that TNF-α is unlikelyto play a key role in the of distant organ failure onset and progression (50).TNF-α exhibits arole in the progression of AP by taking part in regulation of apoptosis (53).TNF-α jointly triggersboth proapoptotic and antiapoptotic mechanisms within pancreatic AR4-2J cells(53).TNF-α might lead to transition of AP from a localized condition to a systemic disorder(55). This evidence concerns the gene TNF and alkaline phosphatase measurement.