ERBB2 and cancer: Moreover, there was no significant difference in GRAP2gene methylation levels among the HR+/HER2-,HR+/HER2+, and HR-/HER2+ molecular subtypes.The overall methylation level of the LCP2 gene incancer-adjacent tissues was significantly higher thanthat in cancer tissues of various subtypes (P<0.005,Figure 2A), and there was no significant difference inmethylation levels within molecular subtype groups.