The RANBP3, LCP2 andGRAP2 genes showed low methylation levels (0.268±0.048, 0.263±0.029, 0.364±0.020) in cancertissue and high levels (0.472±0.065, 0.491±0.036, 0.569±0.042) in cancer-adjacent tissue, withsignificant differences (P<0.005 P<0.005 P<0.005)(Figure 1D). The gene discussed is LCP2; the disease is cancer.