ERBB2 and breast cancer: Interestingly, the methylation level of the RANBP3 gene in cancer tissues of theHR+/HER2- and HR+/HER2+ types was significantlylower than that in the HR-/HER2+ type(P=0.000, P=0.007), suggesting a correlationbetween the methylation level of the RANBP3 geneand HR expression in breast cancer.