Our study revealed that the RANBP3 gene existsin a low methylation state in breast cancer tissue andis correlated with hormone receptor (HR) expression.Considering the characteristic of unchecked proliferationin cancer cells and without accounting for theinfluence of transcription and protein expression factors,we postulate that the RANBP3 gene may be highly expressed in breast cancer due to somedemethylation mechanism, thereby promoting cancercell proliferation. The gene discussed is RANBP3; the disease is breast cancer.