In DKD, Decoy receptor 2 (DCR2), a p53 target gene influencing chemosensitivity by inhibiting the pro-apoptotic activity of the tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), was recently shown to interact with peroxiredoxin 1 (PRDX1) to induce senescence of RTECs, which play an important role in promoting renal fibrosis in DKD [137]. The gene discussed is TNFSF10; the disease is diabetic kidney disease.