This approach has been already tested in an optogenetic mouse model of stroke, where stimulated animals showed a significantly faster recovery phase, with increased expression of protective neurotrophins, markers of plasticity, and significantly better performance in sensory‐motor behavior tests.[72] Contralesional theta‐burst stimulation following stroke also led to a faster and better recovery of the upper limb mobility in human patients.[73] Whether similar benefits are achievable using OEPC remains to be explored. Here, BDNF is linked to Stroke.