Acupuncture may reduce obesity through a variety of ways, as downregulation and decreased synthesis of AgRP and NPY as well as, upregulation and increased synthesis of MSH and POMC in the ARC, the decreased activity of LHA neurons and the increased activity of VMH neurons, a rise in CCK, a reduction in leptin and insulin and increased its sensitivity [55]. The gene discussed is INS; the disease is obesity due to melanocortin 4 receptor deficiency.