The role of SIRT3 in neurodegenerative diseases is not fully understood, while current research suggests that a decline in SIRT3 expression leads to hyperacetylation of hundreds of mitochondrial proteins, associated with abnormalities in the nervous system, death of nerve cells40; Silencing of SIRT3 also leads to oxidative damage to neurons.41 This evidence concerns the gene SIRT3 and neurodegenerative disease.