Other studies reported that the extracellular Alpha‐synuclein (ASN) or transcription factor NRF2 could also regulate the SIRT3 expression in Alzheimer's disease,38, 39 whether these were involved in the change of SIRT3 of postoperative delirium in mice need further investigation in the following studies. The gene discussed is SNCA; the disease is early-onset autosomal dominant Alzheimer disease.