Analysis of the TCGA melanoma cohort described oncogenic activation of driver mutations such as BRAF, NRAS, and CKIT, whereas the tumor suppressor genes identified included CDKN2A, NF1, PTEN, and TP53. Our study adds to the knowledge of melanoma biology by adding miR-876 to the list of tumor suppressors inactivated in melanoma. The gene discussed is PTEN; the disease is melanoma.