CA9 and neoplasm: Among the genes downregulated following miR-876 overexpression were several tumor-promoting genes, including CDC42EP5, CA9, VEGFB, TNFRSF4 and DDR1. VEGFB is a pro-angiogenic gene that has been shown to be regulated by ERK [32], whereas CA9 promotes tumor progression via regulation of HIF1A in hypoxic conditions [33].