Dysferlin/ApoE double knockout (Dysf/ApoE) mice present humanization of muscle phenotypes including fatty/fibrotic infiltration, leading to severe ambulatory dysfunction, a process accelerated by high-fat diet (HFD) [12] and even further by high-cholesterol dietary supplementation [13], providing causal evidence that abnormal cholesterol and lipoprotein metabolism play a detrimental role in MD. Here, DYSF is linked to Menkes disease.